MDMA and Antidepressants (SSRI/SNRI)
Blunts it - don't chase.
Why this happens
Usually flattens MDMA's effect by occupying the transporter it works through. The danger is redosing to feel something. Not a workaround - a medical conversation.
What this means in practice
Not among the most dangerous mixes, but it stacks risks. Keep doses low, stay cool and hydrated, and keep checking in on how you feel.
Warning signs - get help
Call your local emergency number straight away if you notice any of these:
- A high fever or skin that is hot to the touch
- Agitation, confusion or hallucinations
- Rigid, twitching or cramping muscles
- A racing heartbeat
- Heavy sweating or shivering
Information, not medical advice. Threshold does not promote or encourage MDMA use. This exists so that people who make their own choices can make safer, better-informed ones. It is not a substitute for professional care.
Sources
- Acute psychological effects of MDMA are attenuated by the serotonin uptake inhibitor citalopram - Neuropsychopharmacology (2000)
- Duloxetine inhibits effects of MDMA in vitro and in humans (randomized placebo-controlled study) - PLoS ONE (2012)
- Qualitative review of serotonin syndrome, ecstasy (MDMA) and the use of other serotonergic substances: hierarchy of risk - Australian & New Zealand Journal of Psychiatry (2007)