MDMA and Citalopram (Celexa)
Shown in a human study to blunt MDMA's effects; rarely dangerous alone, but redosing is the real risk.
Why this happens
Citalopram is the SSRI used in the human study that first showed MDMA's psychological effects are markedly reduced by a serotonin-uptake inhibitor. It occupies the same transporter MDMA works through.
What this means in practice
Do not try to push through by taking more MDMA - that is where the real risk is. Whether to pause an antidepressant for MDMA is a medical decision, never a DIY one; ask the prescriber.
Warning signs - get help
Call your local emergency number straight away if you notice any of these:
- A high fever or skin that is hot to the touch
- Agitation, confusion or hallucinations
- Rigid, twitching or cramping muscles
- A racing heartbeat
- Heavy sweating or shivering
Information, not medical advice. Threshold does not promote or encourage MDMA use. This exists so that people who make their own choices can make safer, better-informed ones. It is not a substitute for professional care.
Sources
- Acute psychological effects of MDMA are attenuated by the serotonin uptake inhibitor citalopram - Neuropsychopharmacology (2000)
- Qualitative review of serotonin syndrome, ecstasy (MDMA) and the use of other serotonergic substances: hierarchy of risk - Australian & New Zealand Journal of Psychiatry (2007)