MDMA and Cocaine
Heavy heat and heart strain.
Why this happens
Stacks stimulants: higher heart rate, blood pressure, and body temperature - the acute risks that send people to hospital - plus a harsher comedown.
What this means in practice
Best avoided. If they are combined anyway, keep doses low, watch the person closely, and be ready to call for help.
Warning signs - get help
Call your local emergency number straight away if you notice any of these:
- A body temperature that stays high
- Chest pain or a racing, pounding heart
- Confusion, collapse or a seizure
Information, not medical advice. Threshold does not promote or encourage MDMA use. This exists so that people who make their own choices can make safer, better-informed ones. It is not a substitute for professional care.
Sources
- Cardiovascular and temperature adverse actions of stimulants - British Journal of Pharmacology (2021)
- Acute toxic effects of 'Ecstasy' (MDMA) and related compounds: overview of pathophysiology and clinical management - British Journal of Anaesthesia (2006)