MDMA and GHB / GBL
Unpredictable sedation.
Why this happens
A depressant with a narrow margin; dosing is unforgiving, and blackouts and overdose are real risks, made harder to read alongside a stimulant.
What this means in practice
Best avoided. If they are combined anyway, keep doses low, watch the person closely, and be ready to call for help.
Warning signs - get help
Call your local emergency number straight away if you notice any of these:
- Cannot be woken
- Slow, shallow or stopped breathing
- Deep unresponsiveness or blue lips
Information, not medical advice. Threshold does not promote or encourage MDMA use. This exists so that people who make their own choices can make safer, better-informed ones. It is not a substitute for professional care.
Sources
- A comprehensive review of MDMA and GHB: two common club drugs - Pharmacotherapy (2001)
- Acute toxic effects of 'Ecstasy' (MDMA) and related compounds: overview of pathophysiology and clinical management - British Journal of Anaesthesia (2006)