MDMA and Venlafaxine (Effexor)
Tends to blunt MDMA; combined with other serotonergic drugs it adds serotonin-syndrome risk.
Why this happens
Venlafaxine is an SNRI. It blocks the serotonin and noradrenaline transporters MDMA acts on, usually reducing its effect while adding to the overall serotonergic load.
What this means in practice
Do not try to push through by taking more MDMA - that is where the real risk is. Whether to pause an antidepressant for MDMA is a medical decision, never a DIY one; ask the prescriber.
Warning signs - get help
Call your local emergency number straight away if you notice any of these:
- A high fever or skin that is hot to the touch
- Agitation, confusion or hallucinations
- Rigid, twitching or cramping muscles
- A racing heartbeat
- Heavy sweating or shivering
Information, not medical advice. Threshold does not promote or encourage MDMA use. This exists so that people who make their own choices can make safer, better-informed ones. It is not a substitute for professional care.
Sources
- Duloxetine inhibits effects of MDMA in vitro and in humans (randomized placebo-controlled study) - PLoS ONE (2012)
- Qualitative review of serotonin syndrome, ecstasy (MDMA) and the use of other serotonergic substances: hierarchy of risk - Australian & New Zealand Journal of Psychiatry (2007)