The protocol
Every the protocol guide on Threshold Safe, newest first - plain-spoken, evidence-graded, and cited.
Caffeine, Alcohol, and Food Timing: What You Consumed in the 24 Hours Before Shapes What MDMA Does Next
A maintained reference tracker, with a visible review date tied to new pharmacokinetic literature, mapping how common dietary choices (caffeine load, fasted vs.…
Second-Session Calculator: How Prior Exposure Changes Your Risk Profile and What to Adjust
An interactive input tool, fields for time since last session, dose used then, subjective recovery completeness, current medications, that outputs a personalised…
Body-Weight, Sex, and Hormones: Why Standard MDMA Dosing Guidance Does Not Fit Everyone Equally
Pharmacokinetic differences by body composition, biological sex, and hormonal state meaningfully affect MDMA plasma levels and duration, this piece explains the…
Microdosing Tolerance Timetable: A Tracked Log of What the Evidence Says About Receptor Sensitivity, Washout Days, and Protocol Switching
A maintained, date-stamped reference table mapping 5-HT2A downregulation timelines against the major microdosing protocols, so readers can see at a glance why…
Microdosing and Your Menstrual Cycle: What the Limited Evidence Suggests and What to Track
A frank audit of the thin but growing literature on how cycle phase may modulate psilocybin sensitivity and emotional response, paired with a self-tracking template…
Microdosing: What to Do When It Stops Working, or Makes Things Worse
A decision guide for people already mid-protocol who are experiencing tolerance plateau, increased anxiety, emotional blunting, or mood instability, covering what…
The MDMA Supplement Stack: What to Take, and Exactly When
A timing-first protocol for the recovery stack: the days before, the day of, the night of, and the days after - with the one rule that keeps precursors from…
Do Recovery Supplements Actually Work?
We pull every credible human trial and mechanistic study behind the five most-marketed recovery supplements and score each one honestly - separating plausible…