ThresholdSAFE
Honest guidance for altered states
Podcast episode

MDMA Side Effects, Explained: During, the Next Day, and Long-Term

What MDMA actually does to your body and mind, across three timeframes: the acute effects during, the after-effects over the following days, and what's associated with long-term heavy use - plus the red flags.

Aug 13, 2026

What MDMA actually does to your body and mind, across three timeframes: the acute effects during, the after-effects over the following days, and what's associated with long-term heavy use - plus the red flags.

Hosted by June and Rob.

In this episode

  • mdma side effects
  • molly side effects
  • mdma jaw clenching
  • mdma after effects
  • mdma long term effects

References

  • Liechti ME. Effects of MDMA on body temperature in humans. Temperature. 2014.
  • Parrott AC. Human psychobiology of MDMA or 'Ecstasy': an overview. Hum Psychopharmacol. 2013.
  • Vizeli P, Liechti ME. Safety pharmacology of acute MDMA administration. J Psychopharmacol. 2017.

This is harm-reduction information, not medical advice. The lowest-risk option is always not to use. In a crisis, call your local emergency number.

Read the full guide →

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