Harm reduction
Every harm reduction guide on Threshold Safe, newest first - plain-spoken, evidence-graded, and cited.
Set and Setting: A Plain-English Explainer
If you have ever heard people talk about MDMA or psychedelics, you have probably heard the phrase "set and setting." It sounds vague, but it points to something…
Should You Stop Antidepressants to Take MDMA? The Honest Answer
Because SSRIs blunt MDMA, people consider stopping them to feel it. This is the honest walk-through of why that trade is riskier than it sounds - and the questions…
How to Use Fentanyl Test Strips on MDMA (Step by Step)
Fentanyl test strips are cheap and easy to get wrong. This is the step-by-step method for MDMA - dilution, timing, reading a counter-intuitive result, and the…
Hyponatremia: Why Drinking Too Much Water on MDMA Can Kill
One of the saddest MDMA tragedies is the person who died trying to be safe by drinking water. Here is why hyponatremia happens, how to spot it, and how to avoid it.
Is There Fentanyl in MDMA? The Real Risk
The fentanyl-in-MDMA question sits between two bad answers: panic and denial. Here is what the evidence actually supports about contamination, why your reagent kit…
How Often Can You Roll? Tolerance & Spacing
Frequency is the lever that matters most for long-term MDMA risk. This explains tolerance, why the magic fades with frequent use, what the research says about…
Heat and Water on MDMA: The Two Real Dangers
Acute MDMA harm is dominated by temperature and fluid balance, not the dose alone. This is how overheating and water intake actually hurt people - and the practical…
Dangerous MDMA Combinations: What You Should Never Mix
Some MDMA combinations are uncomfortable; a few are deadly. This is a clear, prioritised guide to the interactions that matter most - especially antidepressants and…
Is It Actually MDMA? How to Test What's in Your Molly
A huge share of what's sold as molly isn't MDMA at all. Testing is the highest-leverage safety step there is. Here's what reagent kits and fentanyl strips do, what…
How Much MDMA Is Too Much? A Body-Weight Dosing Guide
Most of the harm from MDMA comes from dosing it like there's no ceiling. This guide covers body-weight dosing, the first-timer rule, the practical maximum, and why…
A Science-Based MDMA Harm-Reduction Protocol
A practical before/during/after harm-reduction protocol for MDMA, covering dosing limits, hydration and temperature, and the evidence-backed supplement stack - plus…
Set and Setting: Mindset, Place and People on MDMA
"Set" is your mindset; "setting" is where you are and who you are with. Together they shape an experience more than the dose does - the same dose can be joyful or…
MDMA Emergencies: How to Spot One and Respond
A calm, practical emergency guide: the signs that mean call for help now, exactly what to do for each one, the recovery position, what to say to responders, and the…
What Is MDMA? Effects and What to Expect
The plain version: what MDMA actually is, how a typical experience unfolds hour by hour, and the questions worth asking before you use.
One calm email a week
New guides, episodes, and drug-checking alerts. No spam, unsubscribe anytime.