Harm reduction
Every harm reduction guide on Threshold Safe, newest first - plain-spoken, evidence-graded, and cited.
Your Ears After MDMA: A Noise-Exposure Ledger for the Morning After
A damage-state checklist and decision guide for hearing, ringing, muffling, one-sided loss, that cross-references the MDMA-specific vasoconstrictive mechanism…
Driving After Psilocybin: A Jurisdiction-by-Jurisdiction Impairment and Legal Exposure Table
A structured table, not prose, mapping what psychomotor impairment research says about psilocybin's duration of perceptual and cognitive effects against legal…
Cardiovascular Stress During MDMA: What Your Heart Is Actually Doing and Who Should Pay Attention
MDMA's acute cardiovascular load, tachycardia, blood-pressure spikes, increased oxygen demand, is rarely explained in terms a person with a borderline ECG or a…
Grief, Trauma History, and Psilocybin: Preparing for What the Experience May Surface
People with unprocessed grief or trauma history face a specific preparation challenge that is neither a contraindication nor a simple 'set and setting' question , …
Before You Book the Retreat: Eight Questions Your Medical History Requires You to Answer First
Retreat intake forms ask about medications but rarely probe the contraindications that matter, cardiac history, personal or family psychiatric history, seizure…
Psilocybin Marketing Claims vs. the Peer-Reviewed Record: A Scored Checklist
A line-by-line audit of the most common commercial claims, neuroplasticity windows, default mode network reset, addiction interruption, scored against what the…
Functional Mushroom Blends Alongside Psilocybin: What Lion's Mane, Reishi, and Cordyceps Actually Interact With
Stacking functional mushrooms with psilocybin is marketed aggressively as synergistic, but the interaction evidence, particularly for lion's mane's NGF…
Microdosing While Medicated: What We Know About Combining Sub-Perceptual Doses With SSRIs, Mood Stabilisers, and ADHD Medications
The evidence, and the honest gaps in it, for people who are already on a prescription and are considering or already microdosing, covering pharmacodynamic…
Psilocybin and Pre-Existing Mental Health Diagnoses: A Condition-by-Condition Risk Table
A structured lookup table, not a prose article, mapping specific diagnoses (bipolar I and II, borderline personality, schizophrenia spectrum, OCD, PTSD,…
Psilocybin and Your Prescriptions: A Drug-Interaction Table for the Medications That Actually Matter
A maintained, scannable reference table mapping psilocybin against the most commonly prescribed drug classes, antihypertensives, triptans, stimulants, mood…
What a GP Needs to Know: A Clinician's Briefing on Patients Who Use MDMA, Psilocybin, or Ketamine
A structured, citation-grounded briefing, formatted as a clinical reference, not a patient explainer, covering drug interactions with common prescriptions,…
Where Psilocybin Stands Legally: A Plain-English Explainer
The legal status of psilocybin - the active compound in magic mushrooms - is one of the most confusing parts of this whole subject.
The Worried Parent's Field Guide: What to Do (and Not Do) When Your Adult Child Tells You They're Going to a Psychedelic Retreat
A non-judgmental, evidence-grounded resource written for the parent who just received news they didn't expect and has no frame for evaluating risk, legitimacy, or…
What DanceSafe Can't Tell You at the Tent: Harm Reduction That Starts Before the Festival and Lasts Two Weeks After
We extend DanceSafe's event-focused model into the pre-loading and post-event recovery windows - covering physiological preparation, the fentanyl and adulterant…
Psilocybin vs MDMA vs Ketamine: How Recovery Differs
Different substances, different recoveries. How psilocybin, MDMA and ketamine each affect the brain and body, what the aftermath of each looks like, and how…
Psilocybin Dosage: What Each Gram Range Actually Does
Mushroom dosing is genuinely tricky because potency varies wildly between batches and species. This covers the dose levels by dried weight, why a scale isn't…
Psilocybin Interactions: The Medications That Matter
Psilocybin is physiologically gentle, but a few interactions matter a great deal - one (lithium) is a serious seizure risk. A clear guide to antidepressants,…
Set and Setting: How to Avoid a Bad Mushroom Trip
With psilocybin, the dose opens the door but set and setting decide what's on the other side. The research-backed essentials of mindset, environment, a sitter,…
MDMA and Antidepressants: SSRIs, SNRIs, MAOIs and Serotonin Syndrome
Antidepressants and MDMA both act on serotonin, but the interactions split sharply: some just flatten the effect, one class can kill you. Here is the clear version,…
Set and Setting: A Plain-English Explainer
If you have ever heard people talk about MDMA or psychedelics, you have probably heard the phrase "set and setting." It sounds vague, but it points to something…
Should You Stop Antidepressants to Take MDMA? The Honest Answer
Because SSRIs blunt MDMA, people consider stopping them to feel it. This is the honest walk-through of why that trade is riskier than it sounds - and the questions…
How to Use Fentanyl Test Strips on MDMA (Step by Step)
Fentanyl test strips are cheap and easy to get wrong. This is the step-by-step method for MDMA - dilution, timing, reading a counter-intuitive result, and the…
Hyponatremia: Why Drinking Too Much Water on MDMA Can Kill
One of the saddest MDMA tragedies is the person who died trying to be safe by drinking water. Here is why hyponatremia happens, how to spot it, and how to avoid it.
Is There Fentanyl in MDMA? The Real Risk
The fentanyl-in-MDMA question sits between two bad answers: panic and denial. Here is what the evidence actually supports about contamination, why your reagent kit…
How Often Can You Roll? Tolerance & Spacing
Frequency is the lever that matters most for long-term MDMA risk. This explains tolerance, why the magic fades with frequent use, what the research says about…
Heat and Water on MDMA: The Two Real Dangers
Acute MDMA harm is dominated by temperature and fluid balance, not the dose alone. This is how overheating and water intake actually hurt people - and the practical…
Dangerous MDMA Combinations: What You Should Never Mix
Some MDMA combinations are uncomfortable; a few are deadly. This is a clear, prioritised guide to the interactions that matter most - especially antidepressants and…
Is It Actually MDMA? How to Test What's in Your Molly
A huge share of what's sold as molly isn't MDMA at all. Testing is the highest-leverage safety step there is. Here's what reagent kits and fentanyl strips do, what…
How Much MDMA Is Too Much? A Body-Weight Dosing Guide
Most of the harm from MDMA comes from dosing it like there's no ceiling. This guide covers body-weight dosing, the first-timer rule, the practical maximum, and why…
A Science-Based MDMA Harm-Reduction Protocol
A practical before/during/after harm-reduction protocol for MDMA, covering dosing limits, hydration and temperature, and the evidence-backed supplement stack - plus…
MDMA Emergencies: How to Spot One and Respond
A calm, practical emergency guide: the signs that mean call for help now, exactly what to do for each one, the recovery position, what to say to responders, and the…
What Is MDMA? Effects and What to Expect
The plain version: what MDMA actually is, how a typical experience unfolds hour by hour, and the questions worth asking before you use.